And hey, Id love to chat with you about your experiences
The proposed mechanisms of diabetes-related NDs include cerebral insulin resistance (IR), vascular endothelial dysfunction, inflammation, bloodbrain barrier injury, white matter disease of vascular origin, demyelination and axonal loss, and peroxidative membrane injury.11 Among these mechanisms, brain IR may play a primary role, and it is worth noting that neurologic complications may already occur with prediabetes IR.12 Oxidative stress,13 mitochondrial dysfunction,14 and endoplasmic reticulum (ER) stress15 are all involved in NDs induced by brain IR
In my practice I have seen patients make similar gains to semaglutide, even while staying on lower doses of tirzepatide
This phenomenon can be confusing and frustrating, but it doesn't mean the medication isn't working
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